The aim of this paper is to study a deep connection between local cohomology annihilators and Macaulayfication and arithmetic Macaulayfication over a local ring. Local cohomology annihilators appear through the notion of p-standard system of parameters. For a local ring, we prove an equivalence of the existence of Macaulayfications, the existence of a p-standard system of parameters, being a quotient of a Cohen-Macaulay local ring, and the verification of Faltings’ Annihilator theorem. For a finitely generated module which is unmixed and faithful, we prove an equivalence of the existence of an arithmetic Macaulayfication and the existence of a p-standard system of parameters; and both are proved to be equivalent to the existence of an arithmetic Macaulayfication on the ground ring. A connection between Macaulayfication and universal catenaricity is also discussed.